推荐阅读原文：
Oligodendrocyte-derivedextracellularvesiclesasantigen-specifictherapyforautoimmuneneuroinflammationinmice.
Autoimmunediseasessuchasmultiplesclerosis(MS)developbecauseoffailedperipheralimmunetoleranceforaspecificself-antigen(Ag).NumerousapproachesforAg-specificsuppressionofautoimmuneneuroinflammationhavebeenproveneffectiveinexperimentalautoimmuneencephalomyelitis(EAE),ananimalmodelofMS.OnesuchapproachisintravenoustoleranceinductionbyinjectingamyelinAgusedfortriggeringEAE.However,thetranslationofthisandsimilarexperimentalstrategiesintotherapyforMShasbeenhamperedbyuncertaintyregardingrelevantmyelinAgsinMSpatients.Toaddressthisissue,wedevelopedatherapeuticstrategythatreliesonoligodendrocyte(Ol)-derivedextracellularvesicles(Ol-EVs),whichnaturallycontainmultiplemyelinAgs.IntravenousOl-EVinjectionreduceddiseasepathophysiologyinamyelinAg-dependentmanner,bothprophylacticallyandtherapeutically,inseveralEAEmodels.ThetreatmentwassafeandrestoredimmunetolerancebyinducingimmunosuppressivemonocytesandapoptosisofautoreactiveCD4+Tcells.Furthermore,weshowedthathumanOlsalsoreleasedEVscontainingmostrelevantmyelinAgs,providingabasisfortheiruseinMStherapy.Thesefindingsintroduceanapproachforsuppressingcentralnervoussystem(CNS)autoimmunityinamyelinAg-specificmanner,withouttheneedtoidentifythetargetAg.
中国干细胞集团有限公司
转载请注明：http://www.ebsaw.com/jblcbx/11197.html
