复发缓解型多发性硬化症中修改的内部和区

德孚医药出版社神经精神疾病和治疗期刊发表了最新文章:复发-缓解型多发性硬化症中修改的内部和区域间同步:一项静息态功能性磁共振成像研究

Backgroundandpurpose:Neuroimagingstudiesofrelapsing–remittingmultiplesclerosis(RRMS)havefoundstructuraldisconnectionandlarge-scaleneuralnetworkdysfunction.However,fewstudieshaveexploredthelocalbrainactivityofRRMSpatientsintherestingstate.Patientsandmethods:Inthisstudy,regionalhomogeneity(ReHo)andresting-statefunctionalconnectivity(FC)wereusedtoinvestigateintra-andinterregionalsynchronizedactivityin22patientswithRRMSand22matchedhealthycontrols(HCs).Results:ComparedwithHCs,patientswithRRMSshowedsignificantlydecreasedReHointheleftinsulaandrightcaudate.Throughfurtherseed-basedFCanalysis,wefounddecreasedFCbetweentheleftinsulaandleftprecentralgyrusinpatientswithRRMS







































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