RadiologyresearchersatTheUniversityofTexasHealthScienceCenteratHouston(UTHealth)havefoundevidencethatmultiplesclerosis（多发性硬化）affectsanareaofthebrainthatcontrolscognitive1,sensory2andmotorfunctioningapartfromthedisablingdamagecausedbythediseasesvisiblelesions.Thethalamus（丘脑）ofthebrainwasselectedasthebenchmarkforthestudyconductedbyfaculty3attheUTHealthMedicalSchool.LeadresearchersincludeKhaderM.Hasan,Ph.D.,associateprofessor,andPonnadaA.Narayana,Ph.D.,professoranddirectorofMagneticResonance4Imaging(MRI)intheDepartmentofDiagnosticandInterventional5Imaging;andJerryS.Wolinsky,M.D.,theBartelsFamilyandOpalC.RankinProfessorintheDepartmentofNeurology.
ResultsoftheresearchwerepublishedinarecenteditionofTheJournalofNeuroscience.
Thethalamusisacentralareathatrelatestotherestofthebrainandactsasthepostoffice,saidHasan,firstauthorofthepaper.Italsoisanareathathastheleastamountofdamagefromlesions（损害）inthebrainbutweseevolumeloss,soitappearsotherbraindamagerelatedtothediseaseisalsooccurring.
Researchershaveknownthatthethalamuslosesvolumeinsizewithtypicalaging,whichacceleratesafterage70.TheUTHealthmultidisciplinaryteamspurposewastoassessiftherewasmorevolumelossinpatientswithmultiplesclerosis,whichcouldexplainthedementia-relateddeclineassociatedwiththedisease.
Multiplesclerosispatientshavecognitivedeficits6andthethalamusplaysanimportantroleincognitivefunction.Thelesionswecanseebutthereissubclinicalactivityinmultiplesclerosiswhereyoucantseethechanges,saidseniorauthorNarayana.Thereareneurodegenerativechangesevenwhenthebrainlooksnormalandwesawthisdamageearlyinthediseaseprocess.
Forthestudy,researchersusedpreciseimagingbythepowerful3TesslaMRIscannerto北京最大的白癜风医院北京白癜风治好多少钱
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